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Seminar Series There are currently no seminars scheduled.…
Summer School, June 2009 Photos from the London Pain Consortium Summer School, held 21st-26th June 2009 in El Escorial, Madrid, Spain.

There are currently no summer schools scheduled. Please continue to check the website for updates.
Archive workshop and seminar slides Professor Peter Karmerman…
 
Current Research
In vivo gene knock-down and knock-out in spinal cord and DRG
The development and maintenance of chronic pain is a very complex process that most likely involves very local and specific changes in receptors and molecules that otherwise have a very broad distribution and function.

To study these changes, it is therefore necessary to employ methods that have very targeted and localised effects. Particularly in vivo this can present a challenge.

The aim of the current project is to develop methods for localised, in vivo gene knock-down or gene knock-out in the spinal cord and dorsal root ganglia. We are trialling intrathecal injections of naked siRNA and are in the process of generating a transgenic mouse with a floxed target gene which will be used for localised gene deletions using AAV-Cre virus injections.