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Current Research
In vivo gene knock-down and knock-out in spinal cord and DRG
The development and maintenance of chronic pain is a very complex process that most likely involves very local and specific changes in receptors and molecules that otherwise have a very broad distribution and function.

To study these changes, it is therefore necessary to employ methods that have very targeted and localised effects. Particularly in vivo this can present a challenge.

The aim of the current project is to develop methods for localised, in vivo gene knock-down or gene knock-out in the spinal cord and dorsal root ganglia. We are trialling intrathecal injections of naked siRNA and are in the process of generating a transgenic mouse with a floxed target gene which will be used for localised gene deletions using AAV-Cre virus injections.