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Summer School, June 2009 Photos from the London Pain Consortium Summer School, held 21st-26th June 2009 in El Escorial, Madrid, Spain.

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Chronic pain: the search for a killer

Researchers engaging with local communities

Researchers’ discovery of why sunburn hurts reveals possible target for new pain relief drugs

New award funding of LPC

UK researchers tackle pain

Imperial College and the London Pain Consortium partner with a Japanese chemical company to fight chronic pain

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Walking on Fire click here

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London Pain Consortium: key Discoveries

Reserachers: Pain killers click here

Painstaking research - tackling chronic pain click here

The London Pain Consortium making a difference
Wellcome Trust conference The Challenges of Chronic Pain

11-13 March 2015
Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

Abstract deadline: 30 January 2015
Registration deadline: 16 February 2015

For more information
click here

 
Current Research
In vivo gene knock-down and knock-out in spinal cord and DRG
The development and maintenance of chronic pain is a very complex process that most likely involves very local and specific changes in receptors and molecules that otherwise have a very broad distribution and function.

To study these changes, it is therefore necessary to employ methods that have very targeted and localised effects. Particularly in vivo this can present a challenge.

The aim of the current project is to develop methods for localised, in vivo gene knock-down or gene knock-out in the spinal cord and dorsal root ganglia. We are trialling intrathecal injections of naked siRNA and are in the process of generating a transgenic mouse with a floxed target gene which will be used for localised gene deletions using AAV-Cre virus injections.