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Current Research
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Higher level processing of sensory messages in different pain states
In chronic pain states, pain can persist even after local recovery of damaged tissue and does not always reflect the degree of tissue damage. On the other hand, while nociceptive pain is elicited by stimulation of the sensory endings in the tissue, neuropathic pain (
Protein expression profiling of laser microdissected-dorsal horn laminae of chronic pain model rats.
Many aspects of chronic pain involve related events at dorsal horn synapses, namely synaptic plasticity in spinal dorsal horn neurons. We combine laser scanning microdissector, 1D/2D SDS-PAGE, and mass spectrometry to identify changes in protein expressions in ch
Pan-DRG neuronal gene ablation for mechanistic studies into neuropathic pain
We are continuing studies on gene ablation in sets of sensory neurons. The present project involved the production of a Cre-ErT2 (tamoxifen-inducible Cre) BAC mouse driven by a pan-DRG neuron promoter for advillin/Pervin in collaboration with Professor Fan Wang (Duke University.
Experimental pain models in humans and heritability of pain traits
Project 1
We are developing the model of UVB irradiation as a translational model of experimental pain in humans. UVB irradiation leads to hypersensitivity to both mechanical and thermal stimuli as well as localised erythema. We have adapted this model for use in both humans and